CURRICULUM VITAE

CONTACT INFORMATION

Email: NDharia@mednet.ucla.edu

EDUCATION

1999-2003 BA Asian Studies (Highest Distinction) The University of Iowa
  BS Biochemistry (Honors, Highest Distinction) The University of Iowa
  BS Computer Science (Highest Distinction) The University of Iowa
  BS Mathematics (Highest Distinction) The University of Iowa
2005-2009 PhD Biology The Scripps Research Institute
2003-2011 MD Medical Scientist Training Program University of California - San Diego

POSTDOCTORAL TRAINING

2011-present Internship and Residency in Pediatrics, University of California - Los Angeles Medical Center

PROFESSIONAL AND RESEARCH EXPERIENCE

2000 Internship, Information Services, John Deere Product Engineering Center, Waterloo, Iowa
2001 Internship, Drivetrain Engineering, John Deere Waterloo Works, Waterloo, Iowa
2001-2003 Undergraduate Independent Research, Laboratory of Adrian H. Elcock, PhD, Department of Biochemistry, The University of Iowa
2002 Summer Undergraduate MSTP Research Scholar, Laboratory of Larry Tobacman, MD, Department of Biochemistry, The University of Iowa
2006-2009 Graduate Student, Laboratory of Elizabeth A. Winzeler, PhD, Department of Cell Biology, The Scripps Research Institute

CLINICAL EXPERIENCE

2003-2007 Volunteer and Lab Manager, Student-Run Free Clinic, University of California - San Diego
2010 International Medical Student Rotation, Department of Pediatrics, Seth GS Medical College and King Edward Memorial Hospital, Mumbai, India

TEACHING AND MENTORSHIP

2001-2003 Peer Tutor, New Dimensions in Learning, The University of Iowa
2008 Teaching Assistant, Human Anatomy, School of Medicine, University of California - San Diego
2011 Senior Peer Mentor, School of Medicine, University of California - San Diego

HONORS AND AWARDS

1999 Honors Program Dean’s Scholarship, The University of Iowa
1999-2003 President’s and Dean’s List, The University of Iowa
2002 Phi Beta Kappa
2003 Highest Distinction, The University of Iowa
2003-2011 Honors in Introduction to Clinical Medicine, Histology, Pediatric Clerkship, Surgery Clerkship, Radiology Body Computed Tomography, and Pediatric Inpatient Subinternship, School of Medicine, University of California - San Diego
2009 First Place Poster, Systems to Synthesis Symposium, San Diego Consortium for Systems Biology

ORGANIZATIONAL ACTIVITIES

2007-2008 Website Manager, Society of Fellows, The Scripps Research Institute
2007-present Website Manager, Winzeler Laboratory, The Scripps Research Institute

EDITORIAL RESPONSIBILITIES

Ad hoc reviewer for PLoS ONE

PEER-REVIEWED PUBLICATIONS

1. Dharia NV, Sidhu ABS, Cassera MB, Westenberger SJ, Bopp SER, Eastman RT, Plouffe D, Batalov S, Park, DJ, Volkman SK, Wirth DF, Zhou Y, Fidock DA, Winzeler EA. (2009) Use of high-density tiling microarrays to globally identify mutations and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biology, 10(2):R21.
   [ PubMed  |  Journal ]   <Highly Accessed>
2. Westenberger SJ, Cui L, Dharia N, Winzeler E, Cui L. (2009) Genome-wide nucleosome mapping of Plasmodium falciparum reveals histone-rich coding and histone-poor intergenic regions and chromatin remodeling of core and subtelomeric genes. BMC Genomics, 10:610.
   [ PubMed  |  Journal ]   <Highly Accessed>
3. Dharia NV, Chatterjee A, Winzeler EA. (2010) Genomics and systems biology in malaria drug discovery. Current Opinions in Investigational Drugs, 11(2):131-8.
   [ PubMed  |  Journal ]
4. Westenberger SJ, McClean CM, Chattopadhyay R, Dharia NV, Carlton JM, Barnwell JW, Collins WE, Hoffman SL, Zhou Y, Vinetz JM, Winzeler EA. (2010) A systems-based analysis of Plasmodium vivax lifecycle transcription from human to mosquito. PLoS Neglected Tropical Diseases, 4(4):e653.
   [ PubMed  |  Journal ]
5. Rottmann M, McNamara C, Yeung BKS, Lee MCS, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, González-Páez GE, Lakshminarayana SB, Goh A, Suwanarusk R, Jegla T, Schmitt EK, Beck HP, Brun R, Nosten F, Renia L, Dartois V, Keller TH, Fidock DA, Winzeler EA, Diagana TT. (2010) Spiroindolones, a potent compound class for the treatment of malaria. Science, 329(5996):1175-80.
   [ PubMed  |  Journal ]
6. Dharia NV, Plouffe D, Bopp SER, González-Páez GE, Lucas C, Salas C, Soberon V, Kochel TJ, Bacon DJ, Winzeler EA. (2010). Genome-scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin resistant parasites. Genome Research, 20(11):1534-44.
   [ PubMed  |  Journal  |  Press Release ]
7. Dharia NV, Bright AT, Westenberger SJ, Barnes SW, Batalov S, Kuhen K, Borboa R, Federe GC, McClean CM, Vinetz JM, Neyra V, Llanos-Cuentas A, Barnwell JW, Walker JR, Winzeler EA. (2010). Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes. PNAS, 107(46):20045-50.
   [ PubMed  |  Journal ]
8. Istvan ES, Dharia NV, Bopp SE, Gluzman I, Winzeler EA, Goldberg DE. (2011). Validation of isoleucine utilization targets in Plasmodium falciparum. PNAS, 108(4):1627-1632.
   [ PubMed  |  Journal ]
9. Eastman RT, Dharia NV, Winzeler EA, Fidock DA. (2011). Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites. Antimicrobial Agents and Chemotherapy, 55(8):3908-16.
   [ PubMed  |  Journal ]
10. Nam TG, McNamara CW, Bopp S, Dharia NV, Meister S, Bonamy GM, Plouffe DM, Kato N, McCormack S, Bursulaya B, Ke H, Vaidya AB, Schultz PG, Winzeler EA. (2011). A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor. ACS Chemical Biology, 6(11):1214-22.
    [ PubMed  |  Journal ]
11. Meister S, Plouffe DM, Kuhen KL, Bonamy GMC, Wu T, Barnes SW, Bopp SE, Borboa R, Bright AT, Che J, Cohen S, Dharia NV, Gagaring K, Gettayacamin M, Gordon P, Groessl T, Kato N, Lee MCS, McNamara CW, Fidock DA, Nagle A, Nam TG, Richmond W, Roland J, Rottmann M, Zhou B, Froissard P, Glynne RJ, Mazier D, Sattabongkot J, Schultz PG, Tuntland T, Walker JR, Zhou Y, Chatterjee A, Diagana TT, Winzeler EA. (2011). Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science, 334(6061):1372-77.
    [ PubMed  |  Journal ]

DISSERTATIONS

1. Dharia NV. (2003) Molecular dynamics simulation of substrate channeling. Undergraduate Honors Thesis. Department of Biochemistry, The University of Iowa, Iowa City, Iowa.
   [ Honors Theses 2003 ]
2. Dharia NV. (2009) Plasmodium evolution and drug resistance in vitro and in populations using whole genome technologies. Doctor of Philosophy (PhD) Thesis in the Subject of Biology. The Scripps Research Institute, La Jolla, California.
   [ Abstract ]

POSTERS PRESENTED AT NATIONAL AND INTERNATIONAL MEETINGS

1. Dharia NV, Westenberger S, Winzeler EA. (2007) Globally identifying mutations in Plasmodium falciparum using high-density tiling microarrays. Molecular Parasitology Meeting (MPM) XVIII, Woods Hole, Massachusetts, 17 September 2007.
   [ Abstract  |  View Poster ]
2. Dharia NV, Westenberger SJ, Sidhu ABS, Eastman RT, Cassera MB, Plouffe D, Bacon DJ, Espinosa B, Fidock DA, Winzeler EA. (2008) Elucidating mechanisms of drug resistance and determining population genetic structures in Plasmodium falciparum using high-density microarrays. Web poster. Molecular Parasitology Meeting (MPM) XIX, Woods Hole, Massachusetts, 23 September 2008.
   [ Abstract ]
3. Dharia NV, Westenberger SJ, Sidhu ABS, Eastman RT, Cassera MB, Plouffe D, Bacon DJ, Espinosa B, Fidock DA, Winzeler EA. (2008) Elucidating mechanisms of drug resistance and determining population genetic structures in Plasmodium falciparum using high-density microarrays. Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases (MEEGID) IX, Irvine, California, 1 November 2008.
   [ Abstract ]
4. Dharia NV, Plouffe D, González-Páez GE, Lucas C, Salas C, Soberon V, Bacon DJ, Winzeler EA. (2009) The power of whole-genome data: From Plasmodium falciparum populations to the discovery of drug resistance to guiding public health policy. Fifth Annual BioMalPar Conference on the Biology and Pathology of the Malaria Parasite, Heidelberg, Germany, 18-20 May 2009.

TALKS

1. Globally identifying mutations in Plasmodium falciparum using high-density microarrays. Institute of Childhood and Neglected Diseases Seminar Series, The Scripps Research Institute, La Jolla, California, 14 December 2007.
2. Elucidating mechanisms of drug resistance and determining population genetic structures in Plasmodium falciparum using high-density microarrays. Graduate Program Symposium, The Scripps Research Institute, La Jolla, California, 5 September 2008.
3. Using genomics in malaria: accelerating drug development and understanding population structures. Cell Biology Student and Postdoc Seminar Series, The Scripps Research Institute, La Jolla, California, 24 April 2009.
4. Whole genome methods to study drug resistance and evolution in Plasmodium falciparum. Université de la Méditerranée Seminar, Institut de médecine tropicale du Service de santé des armées, Marseille, France, 15 May 2009.
5. Plasmodium evolution and drug resistance in vitro and in populations using whole genome technologies. PhD Thesis Defense, The Scripps Research Institute, La Jolla, California, 30 July 2009.